Role of Cervical Vasopressin in Vaginal Hysterectomy: A Tertiary Care Level Centre Study

Background: The use of vasoconstrictive drugs like vasopressin in major surgeries like hysterectomy can decrease the morbidity of the patient by controlling the intra-operative blood loss. Materials and Methods: About 80 patients undergoing elective vaginal hysterectomy were selected for the study. They were divided into two groups, in which vasopressin in diluted form was injected pre-operatively in one group, and another group was taken as control. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) for Windows version 19.0 software, Chicago, SPSS Inc. Result: The parameters like duration of surgery, change in vitals during surgery and post-operative complications showed no significant difference in two groups. However, significant difference (P < 0.0001) was seen in the amount of blood loss in two groups. Conclusion: Vasopressin is a drug which can play a key role in changing the percentage of post-operative morbidity in the patients undergoing vaginal hysterectomy by bringing drastic change in the amount of blood loss in the surgery.